Scientific Sources and References

  1. Diet might be able to modify the chemical tags associated with your DNA, called the epigenome. These epigenetic changes affect how genes behave and consequently affect metabolism and secretion of insulin, the hormone that controls your blood sugar levels.

    Live Science, Christopher Wanjek, How Genes and Environment Conspire to Trigger Diabetes

  2. Genes are not fixed, they have "switches" that turn on and off by things like life experiences and environmental influences and can trigger disease.

    Herald-Tribune, Marilynn Preston, You are the switch that can activate your destiny

  3. Gene modifications are reversible through a set of lifestyle changes that fit your unique needs.

    Jinying Zhao, et al., Global DNA Methylation Is Associated With Insulin Resistance

  4. Precision medicine is an approach to disease treatment and prevention that seeks to maximize effectiveness by taking into account your individual variability in genes, environment, and lifestyle.

    Precision Medicine Initiative Working Group Report (pdf)
  5. In community settings, remission of type 2 diabetes does occur without bariatric surgery, but it is very rare.

    Incidence of Remission in Adults With Type 2 Diabetes: The Diabetes & Aging Study
  6. Our results suggest that personalized diets may successfully modify elevated postprandial blood glucose and its metabolic consequences.

    Personalized Nutrition by Prediction of Glycemic Responses
  7. Lifestyle changes and treatment with metformin both reduced the incidence of diabetes in persons at high risk. The lifestyle intervention was more effective than metformin.

    Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin
  8. Intensive lifestyle intervention was associated with a greater likelihood of partial remission of type 2 diabetes compared with diabetes support and education.

    Association of an Intensive Lifestyle Intervention With Remission of Type 2 Diabetes
  9. Type 2 diabetes has long been regarded as inevitably progressive, requiring increasing numbers of oral hypoglycemic agents and eventually insulin, but it is now certain that the disease process can be halted with restoration of normal carbohydrate and fat metabolism.

    Type 2 Diabetes Etiology and reversibility
  10. Addition of nutrigenetically tailored diets resulted in better compliance, longer-term BMI reduction and improvements in blood glucose levels.

    Improved weight management using genetic information to personalize a calorie controlled diet
  11. Results demonstrate that moderate 5% weight loss improves metabolic function in multiple organs simultaneously.

    Effects of Moderate and Subsequent Progressive Weight Loss on Metabolic Function and Adipose Tissue Biology in Humans with Obesity